• About

undocancer

~ Deciphering Today's Cancer News

undocancer

Monthly Archives: May 2016

Promising Strategy in HER2 Positive Breast Cancer

08 Sunday May 2016

Posted by undocancer in breast cancer

≈ Leave a comment

Old_Quadrangle,_Manchester_1

University of Manchester, UK

Recently, in a Cancer Research UK study at the University of Manchester, remarkable results were reported in a clinical study of HER2+ breast cancer. Using the existing drugs trastuzumab (Herceptin) and lapatinib (Tyverb) together right after diagnosis, a quarter of women treated saw tumors shrink considerably, or even disappear, after just an average of 11 days.

Herceptin and Tyverb are not new to breast cancer treatment, but this study shows the possible effects of combining the drugs immediately after diagnosis in a pre-operative treatment. The study included 257 newly diagnosed women with operable, HER2+ tumors. Diagnoses were confirmed with biopsy.

While the trial was not originally designed to study these 2 drugs in this setting, the study was amended midway through as new data showed the synergistic effects of the drug combination. The women were randomized to a control group (no pre-operative treatment), Herceptin only, or the combination treatment for 11 days. Both groups proceeded to undergo surgical resection and receive standard treatment after surgery.

Among those women who received both drugs, 11% had a pathological complete response after surgery and 17% had minimal residual disease. In the control group, nobody showed either response.

References:

  • https://www.sciencedaily.com/releases/2016/03/160310125513.htm

Archives

  • May 2016
  • January 2016
  • April 2015
  • March 2015
  • February 2015
  • January 2015

Enter your email address to follow this blog and receive notifications of new posts by email.

Follow undocancer on WordPress.com

Tags

4-MEI altitude anticonvulsant biologics brain brca1 brca2 breast cancer Caramel Color chemosensitivity testing chlorotoxin coffee colon colorectal curcumin dendritic cells EGCG elevation endometrial cancer esophageal flavonoids gastric genistein genomics glioblastoma glioma green tea harvard immunotherapy individualized treatment Johns Hopkins ketogenic lung cancer melanoma nanoparticle Oleocanthal olive oil oncolytic ovarian oxygen pancreatic personalized medicine phenols polyphenols prostate cancer radiosensitizer resveratrol Science screening skin cancer soft drinks stem cell stomach triple-negative tumor Tumor Paint Vitamin D

Blog at WordPress.com.

Cancel